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 1.                                                                CRISPR tech selectively shreds cancer cells, including "undruggable" cancers ( innovativegenomics.org )   
     470 points by gmays 5 hours ago | hide | 128 comments                                                                                                                   
                                                                                                                                                                             
 2.                                                                I Am Not a Reverse Centaur ( miguelgrinberg.com )                                                         
     160 points by ibobev 2 hours ago | hide | 109 comments                                                                                                                  
                                                                                                                                                                             
 3.                                                                How to setup a local coding agent on macOS ( ikyle.me )                                                   
     121 points by kkm 2 hours ago | hide | 44 comments                                                                                                                      
                                                                                                                                                                             
 4.                                                                Malware developers added nuclear and biological weapons text to to their spyware ( twitter.com/jsrailton )
     170 points by marc__1 4 hours ago | hide | 110 comments                                                                                                                 
                                                                                                                                                                             
 5.                                                                Pirates, a naval warfare game inspired by Sid Meier's Pirates ( piwodlaiwo.github.io )                    
     97 points by iweczek 3 hours ago | hide | 42 comments                                                                                                                   
                                                                                                                                                                             
 6.                                                                Law Enforcement's "Warrior" Problem (2015) ( harvardlawreview.org )                                       
     63 points by bookofjoe 3 hours ago | hide | 40 comments                                                                                                                 
                                                                                                                                                                             
 7.                                                                Where Did Earth Get Its Oceans? Maybe It Made Them Itself ( quantamagazine.org )                          
     81 points by ibobev 4 hours ago | hide | 47 comments                                                                                                                    
                                                                                                                                                                             
 8.                                                                Slightly reducing the sloppiness of AI generated front end ( envs.net )                                   
     131 points by FergusArgyll 5 hours ago | hide | 90 comments                                                                                                             
                                                                                                                                                                             
 9.                                                                Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents ( bitboard.work )                           
     22 points by arcb 3 hours ago | hide | 9 comments                                                                                                                       
                                                                                                                                                                             
10.                                                                A PDF that changes based on how its read ( sgaud.com )                                                    
     87 points by SarthakGaud 3 hours ago | hide | 48 comments                                                                                                               
                                                                                                                                                                             
11.                                                                A dumpster arrived behind my university's library ( yalereview.org )                                      
     131 points by mooreds 6 hours ago | hide | 114 comments                                                                                                                 
                                                                                                                                                                             
12.                                                                AI agent bankrupted their operator while trying to scan DN42 ( lantian.pub )                              
     1345 points by xiaoyu2006 15 hours ago | hide | 484 comments                                                                                                            
                                                                                                                                                                             
13.                                                                Introduction to UEFI HTTP(s) Boot with QEMU/OVMF ( yadutaf.fr )                                           
     47 points by jtlebigot 5 hours ago | hide | 14 comments                                                                                                                 
                                                                                                                                                                             
14.                                                                There Is Life Before Main in Rust ( grack.com )                                                           
     45 points by mmastrac 4 hours ago | hide | 12 comments                                                                                                                  
                                                                                                                                                                             
15.                                                                Maxproof ( arxiv.org )                                                                                    
     118 points by ilreb 8 hours ago | hide | 10 comments                                                                                                                    
                                                                                                                                                                             
16.                                                                Cosmodial Sky Atlas ( killedbyapixel.github.io )                                                          
     13 points by memalign 2 hours ago | hide | 1 comment                                                                                                                    
                                                                                                                                                                             
17.                                                                Show HN: StackScope – I crawled over 40k indie launches to see what they ship ( stackscope.dev )          
     32 points by datafreak_ 5 hours ago | hide | 8 comments                                                                                                                 
                                                                                                                                                                             
18.                                                                If you are asking for human attention, demonstrate human effort ( tombedor.dev )                          
     1413 points by jjfoooo4 21 hours ago | hide | 444 comments                                                                                                              
                                                                                                                                                                             
19.                                                                "Don't You Just Upload It to ChatGPT?" ( correresmidestino.com )                                          
     134 points by speckx 2 hours ago | hide | 118 comments                                                                                                                  
                                                                                                                                                                             
20.                                                                Hazel (YC W24) Is Hiring a Full Stack Engineer ( ycombinator.com )                                        
     7 hours ago | hide                                                                                                                                                      
                                                                                                                                                                             
21.                                                                WASI 0.3 ( bytecodealliance.org )                                                                         
     203 points by mavdol04 6 hours ago | hide | 82 comments                                                                                                                 
                                                                                                                                                                             
22.                                                                A Call to Action: Stop the FCC's KYC Regime ( lopp.net )                                                  
     282 points by FergusArgyll 5 hours ago | hide | 188 comments                                                                                                            
                                                                                                                                                                             
23.                                                                Looking Forward to Postgres 19: It's About Time ( pgedge.com )                                            
     95 points by xngbuilds 3 hours ago | hide | 28 comments                                                                                                                 
                                                                                                                                                                             
24.                                                                Encrypted Spaces An architecture for collaborative applications ( encryptedspaces.org )                   
     49 points by _____k 8 hours ago | hide | 5 comments                                                                                                                     
                                                                                                                                                                             
25.                                                                New privacy frontier: Europe eyes crackdown on smart glasses ( politico.com )                             
     66 points by 1vuio0pswjnm7 3 hours ago | hide | 50 comments                                                                                                             
                                                                                                                                                                             
26.                                                                A jacket that harvests drinking water from the air ( utexas.edu )                                         
     149 points by ilreb 20 hours ago | hide | 96 comments                                                                                                                   
                                                                                                                                                                             
27.                                                                Kimi K2.7-Code: open-source coding model with better token efficiency ( huggingface.co )                  
     364 points by nekofneko 9 hours ago | hide | 197 comments                                                                                                               
                                                                                                                                                                             
28.                                                                Nobody ever gets credit for fixing problems that never happened (2001) [pdf] ( web.mit.edu )              
     701 points by sam_bristow 19 hours ago | hide | 233 comments                                                                                                            
                                                                                                                                                                             
29.                                                                Show HN: Script to bulk delete Claude chats from the web UI ( github.com/matteoleonesi )                  
     46 points by ML0037 5 hours ago | hide | 17 comments                                                                                                                    
                                                                                                                                                                             
30.                                                                Vinyl succumbs to Loudness War: more than just collateral damage (2025) ( magicvinyldigital.net )         
     140 points by sneela 16 hours ago | hide | 216 comments                                                                                                                 
                                                                                                                                                                             
                                                                                                                                                                             
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